HumaCount 5D

5-Part Diff

Importance of white blood cell differential count

Benefits of a 5-part diff
  • Better, targeted assessment of the immune response
  • Reduced number of manual blood smears
  • Faster reporting time
  • Saves costs
5-part diff provides a clear picture of the immune status

The WBC differential divides the white blood cells into the 5 major sub-populations. Each cell type provides information about an immune response or a disease type

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Importance of EOS and NEU separation for a targeted diagnosis
  • A high number of eosinophils EOS indicates a parasitic infection
  • A high number of neutrophils indicates a bacterial infection
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A 3-part system groups cell types, hence providing only limited information on the disease status
  • MID = MON + EOS
  • GRA = NEU + EOS + BAS

For the full picture manual blood smears are required for a high performance or an outstanding 5-part diff system like HumaCount 5D

Innovations you can count on

5-part diff hematology analyzer
  • Small footprint stand-alone system with integrated PC
  • 29 parameters with ATL#% & LIC#%
  • Sample volume: 20 μl
  • Up to 60 samples / hour
  • 2D barcode target value transfer
Direct capillary blood process using OptimalCount Technology
  • Same accuracy compared to venous blood
  • Total capillary blood volume of 20 μl
  • 0 μl dead volume
Distinct 5-part diff
  • Providing excellent differentiation of NEU, EOS, MON, LYM and BAS, based on 3D scatter technology.
Definite immature cell count
  • Quantitative count and percentage value of Large Immature Cells (LIC),
  • Atypical Lymphocytes (ALY).
5-part diff or CBC-count mode switch
  • One click option to switch between full 5-part diff or CBC-count for each sample.

Definite Immature Cell Count

Reliable immune cell analysis (LIC, ALY)

LIC and ALY without blood smear

3D Laser Scatter enables quantitative count and percentage value of Large Immature Cells (LIC) and of Atypical Lymphocytes (ALY).

LIC (blasts)

LIC are an excellent routine parameter indicating the balance between leucocyte production, circulation in the body and consumption due to immune defense. A high number of LICs is often described as a ‘left-shifted’ leukogram, with more banded cells and metamyelocytes present while segmented neutrophils are already depleted in the blood

ALY (lymphoblasts)

ALY (lymphoblasts) are larger than naive lymphocytes. ALY are lymphocytes that have increased in size due to activation by an antigen, which in turn triggers increased synthesis of mRNA and protein. ALY in blood are always an alarm signal. ALY are seen in the blood of patients suffering from acute lymphoblastic leukemia (ALL); viral disease such as cytomegalovirus, Epstein Barr Virus, hepatitis C; bacterial infections such as toxoplasmosis; exposure to radiation; drug and immunization reactions; and other immune responses.